CLS Services

Gepubliceerd: ongeveer 1 maand geleden

DSP Process Engineer

Leiden
Gepubliceerd: ongeveer 1 maand geleden
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CLS Services is a leading professional recruitment agency, specialised in the recruitment and career coaching of people with a background in chemistry & life sciences. For our client, Janssen Vaccines & Prevention, we are searching for a DSP Process Engineer.

Company profile
Janssen Vaccines & Prevention is dedicated to bringing meaningful innovation to global health. They focus on the discovery, development, manufacturing and marketing of vaccines and antibodies to protect people world-wide from infectious diseases.

Department
The ‘Down Stream Processing’ (DSP) department forms part of the Drug Substance Development group and develops & characterises processes for purifying and formulating recombinant viruses from harvest as a vaccine production platform. These processes must be safe, scalable and economically viable. They will be implemented in a GMP pilot plant facility for the production of clinical trial material and scaled-up for commercial production.

Job description
Process development consists of a USP and a DSP department and is responsible for the development of scalable, pharmaceutical-grade production processes for viral vaccines using mammalian cell lines as a production platform. Novel technologies are used to make sure that the processes are safe, reliable, scalable and cost-effective, so that the vaccines can be produced in large quantities at low costs. The developed production processes are transferred into GMP production facilities for the production of clinical batches and scaled-up for commercial production. All activities are performed in close collaboration with other departments.

We are looking for a motivated Process Engineer/Scientist who can design studies and make sure that they can be executed.

You will represent DSP in multidisciplinary project team(s), being responsible for process development in that project, in close connection to all relevant stake holders. In order to develop the process, you translate research goals into actions and accomplish the targets by delivering study designs and study plans, analyse data and write or co-ordinate scientific study reports, all in close connection with the customer.

You ensure a smooth tech transfer of new products in production (either the CTM pilot plant or production) and give for 2nd line support of running production. In addition, you identify possible improvements for increased robust manufacturing and translate this back to development studies.

Who we're looking for
We are looking for an M.Sc. in chemical engineering, microbiology, organic chemistry or similar life science related field with minimum of 5 years of hands-on operational DSP experience (lab, pilot and/or production scale).
Experience:

  • Relevant DSP unit operations are Filtration, Chromatography and UF/DF;
  • Experience with scale-up/scale-down of DSP processes;
  • Good communication skills;
  • Experience with cGMP requirements;
  • Preferably experience with Lean/Process Excellence.


The most important competencies for this position are:
  • Enthusiasm to support production by hands-on presence during production (sometimes travelling required)

Pragmatic;
  • Demonstrated communication capabilities and the ability to bridge between production and development;
  • Data-analysis & report writing;
  • Quality, efficiency, accuracy and reliability of work.


Additional vacancy information
Reference: A2000078
Contract: Temporary contract with CLS Services
Education: WO/MSc.
Terms: Project for at least 1 year.
Contactperson: Claudia Erwich-Faaij
Phone: +31 (0)88 22 77 555

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Fulltime / parttime

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